Just as instruments have evolved from manual pipettes to vast automated instruments, so too has the technology for quality control. When we're using a fourth generation instrument, should be be doing first generation quality control (like the old standby, 1:2s), a practice that was introduced in the 1950's? Dr. Westgard charts the history and progress of QC technology and introduces new tools (QC Selection grids, OPSpecs charts, automated QC selection) that we can use for the 21st century.