EUROPEAN BIOLOGIC GOALS AND CALCULATED BIOLOGIC ALLOWABLE TOTAL ERRORSEUROPEAN BIOLOGIC GOALS AND CALCULATED BIOLOGIC ALLOWABLE TOTAL ERRORSProposed and interim (in parenthesis) quality specifications for total analytical imprecision (CV,%) and inaccuracy (as % maximum allowable deviation) for commonly analysed quantities: these should be achieved in at least 95% of experiments performed. [From Frazer CG, Hyltoft Petersen P, Ricos C, Haeckel R. "Proposed quality specifications for imprecision and inaccuracy of analytical systems for clinical chemistry." Eur J Clin Chem Clin Biochem 1992;30:311-317] The total error is calculated from the equation TE = 1.65 (imprecision) + inaccuracy [From Hyltoft Petersen P, Ricos C, Stockl D, Libeer JC, Baadenhuijsen H, Fraser C, Thienpont L. "Proposed guidelines for the internal quality control of analytical results in the medical laboratory." Eur J Clin Chem Clin Biochem 1996;34:983-999]
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| Quantity | Imprecision % | Inaccuracy % | Total Error % |
| Acid phosphatase | 4.5 | 2.1 (9.0) | 9.5 (16.4) |
| Alanine aminotransferase | 13.6 | 13.6 | 36.0 |
| Alkaline phosphatase | 3.4 | 6.4 | 12.0 |
| Amylase | 3.7 | 6.5 (7.4) | 12.6 (13.5) |
| Aspartate aminotransferase | 7.2 | 6.2 | 18.0 |
| Creatine kinase | 20.7 | 19.8 | 54.0 |
| Gamma-Glutamyl transferase | 7.4 | 21.8 | 34.0 |
| Lactate dehydrogenase | 3.9 | 4.1 (7.8) | 10.5 (14.2) |
| Quantity | Imprecision % | Inaccuracy % | Total Error % |
| Thyroxine (total) | 3.4 (4.1) | 4.1 (6.8) | 9.7 (13.6) |
| Triiodothyronine | 4.0 (4.7) | 5.5 (8.0) | 12.1 (15.8) |
| Digoxin | 3.8 (4.7) | 3.9 | 10.2 (11.7) |
| Transferrin | 2.4 (4.0) | 2.3 (4.8) | 6.3 (11.4) |
| IgG | 1.9 (3.7) | 5.0 | 8.1 (11.1) |
| IgA | 2.2 (3.8) | 12.5 | 16.1 (18.8) |
| IgM | 2.3 (5.4) | 12.7 | 16.5 (21.6) |
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