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Optimal Biological Variation database specifications PDF Print

How good can you get? The Biologic Variation database, compiled by the Spanish CC society and Dr. Carmen Ricos, not only includes desriable specifications for imprecision, bias and total error, but also optimal specifications. For labs in search of "stretch" goals, here's the place to start.

Optimal Specifications for Total Error, Imprecision, and Bias, derived from intra- and inter-individual biologic variation

This most recent and extensive listing of biologic goals has been provided by Ricos C, Alvarez V, Cava F, Garcia-Lario JV, Hernandez A, Jimenez CV, Minchinela J, Perich C, Simon M. "Current databases on biologic variation: pros, cons and progress." Scand J Clin Lab Invest 1999;59:491-500. This database was most recently updated in 2012: see what was updated here.

 

    Analyte   Biologic Variation   Optimal Specification  
CVI CVG CV(%) Bias (%) TEa
U- α-Amylase 94.0 46.0 23.5 13.1 51.9
U- α-Amylase pancreatic 39.0 78.4 9.8 10.9 27.0
S- Alanine aminotransferase 18.0 42.0 4.5 5.7 13.1
U- Albumin 36.0 55.0 9.0 8.2 23.1
U- Albumin/creatinine 30.5 32.5 7.6 5.6 18.2
U- Aldosterone 32.6 39.0 8.2 6.4 19.8
S- Bilirubin 23.8 39.0 6.0 5.7 15.5
S- Bilirubin, conjugated 36.8 43.2 9.2 7.1 22.3
U- Calcium, concentration 27.5 36.6 6.9 5.7 17.1
U- Calcium, output 26.2 27.0 6.6 4.7 15.5
S- Creatine kinase 22.8 40.0 5.7 5.8 15.2
S- γ-Glutamyltransferase 13.8 41.0 3.5 5.4 11.1
S- Iron 26.5 23.2 6.6 4.4 15.3
U- Magnesium, concentration 45.4 37.4 11.4 7.4 26.1
U- Magnesium, output 38.3 37.6 9.6 6.7 22.5
U- Phosphate, concentration 26.4 26.5 6.6 4.7 15.6
U- Phosphate, output 18.0 22.6 4.5 3.6 11.0
U- Potassium, concentration 27.1 23.2 6.8 4.5 15.6
U- Potassium, output 24.4 22.2 6.1 4.1 14.2
U- Protein, concentration 39.6 17.8 9.9 5.4 21.8
U- Protein, output 35.5 23.7 8.9 5.3 20.0
U- Sodium, concentration 24.0 26.8 6.0 4.5 14.4
U- Sodium, output 28.7 16.7 7.2 4.2 16.0
S- Triglyceride 20.9 37.2 5.2 5.3 14.0
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